|The IKBKB ikbkb (Catalog #MBS9230770) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The IKBKB ikbkb product has the following accession number(s) (GI #299758411) (NCBI Accession #NP_001177649.1) (Uniprot Accession #O14920). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Cellular Location: Cytoplasm. Nucleus. Membrane raft. Note: Colocalized with DPP4 in membrane rafts. Tissue Location: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood. IKBKB also interacts with the following gene(s): CHUK, IKBKG, MAP3K7, NFKB1, NFKBIA, NFKBIB, RELA, TNFRSF1A, TRAF2, UBC. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. Atherosclerosis, Breast Neoplasms, Cell Transformation, Neoplastic, Fibrosis, Inflammation, Insulin Resistance, Liver Diseases, Lung Neoplasms, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to Phospho-IKKB(S692) Blocking Peptide.