Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Blog  rightarrow IKBKB blocking peptide  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
separator
 • Goat anti Mouse IgG + IgM (H + L) (FITC) secondary antibody blog
 • DSG3 elisa kit blog
 • TMPRSS11BNL shrna blog
 • ERP44 sirna blog
 • FOXP3 elisa kit blog
 • FANCD2 sirna blog
 • TLR2 recombinant protein blog
 • anti-IPAF antibody blog
 • Ethyleneurea inhibitor blog
 • anti-IL6 antibody blog
 • anti-HCK antibody blog
 • anti-CD99 antibody blog
 • IgG immunoglobulin blog
 • anti-cd3e antibody blog
 • anti-CD94 antibody blog
 • CASP14 elisa kit blog
 • TRPC1 sirna blog
 • Abacavir 5'-Phosphate biochemical blog
 • GREB1 sirna blog
 • Angiotensin II [Sar1, Thr8] peptide blog
separator
Blog Categories separator
separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
separator
Our Best Sellers moreseparator
separator
 • PNN Antibody
 • GJA3 Antibody
 • Aquaporin 2, Collecting Duct (AQP-2) ELISA Kit
 • Lipolysaccharide Binding Protein (LBP) ELISA Kit
 • Glucose Regulated Protein 94 (GRP94) ELISA Kit
 • Glucose Transporter 1 (GLUT-1) ELISA Kit
 • Cathelicidin Antimicrobial Peptide (CAMP) ELISA Kit
 • Collagen Type X (COL10) ELISA Kit
 • Neuronal Nuclear Autoantibody 1 (NNAA) ELISA Kit
 • Dengue Fever Antibody (DF) ELISA Kit
 • Endothelial Nitric Oxide Synthase (ENOS) ELISA Kit
 • Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit
 • Cd5 Antigen-Like-Scavenger Receptor Cysteine Rich Family (CD... ELISA Kit
 • Small Breast Epithelial Mucin (SBEM) ELISA Kit
 downarrow more ...
separator

IKBKB blocking peptide product blog

separator
Posted on 2016-07-23 22:17:57 by mybiosource_staff
Share it on ...     
separator
separator
Tags: IKBKB; Blocking Peptide; IKKB (S692); IKBKB blocking peptide;
separator
The IKBKB ikbkb (Catalog #MBS9230770) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.

The IKBKB ikbkb product has the following accession number(s) (GI #299758411) (NCBI Accession #NP_001177649.1) (Uniprot Accession #O14920). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

IKBKB ikbkb

Cellular Location: Cytoplasm. Nucleus. Membrane raft. Note: Colocalized with DPP4 in membrane rafts. Tissue Location: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood. IKBKB also interacts with the following gene(s): CHUK, IKBKG, MAP3K7, NFKB1, NFKBIA, NFKBIB, RELA, TNFRSF1A, TRAF2, UBC. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. Atherosclerosis, Breast Neoplasms, Cell Transformation, Neoplastic, Fibrosis, Inflammation, Insulin Resistance, Liver Diseases, Lung Neoplasms, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to Phospho-IKKB(S692) Blocking Peptide.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions