|The IFNLR1 ifnlr1 (Catalog #MBS9228839) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The IFNLR1 ifnlr1 product has the following accession number(s) (GI #25014103) (NCBI Accession #NP_734464.1) (Uniprot Accession #Q8IU57). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
Cellular Location: Membrane; Single-pass type I membrane protein. Tissue Location: Widely expressed. The following patways have been known to be associated with this gene. Intestine, Lung, Lymph, Lymph Node, Prostate tissues are correlated with this protein. Carcinoma, Carcinoma, Hepatocellular, Fatty Liver, Fibrosis, Hyperplasia, Liver Cirrhosis, Liver Diseases, Lung Diseases, Lung Neoplasms, Nervous System Diseases are some of the diseases may be linked to IL28RA Blocking Peptide (C-term).