HTRA3 blocking peptide product blog
Tags: Blocking Peptide; HTRA3; HTRA3 blocking peptide;
The HTRA3 htra3 (Catalog #MBS9219843) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The HTRA3 htra3 product has the following accession number(s) (GI #21542412) (NCBI Accession #P83110.2) (Uniprot Accession #P83110). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.
Cellular Location: Secreted. Note: Secretion increased during decidualization of endometrial stromal cells. Tissue Location: Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. Bone, Brain, Embryonic Tissue, Heart, Kidney, Lung, Muscle, Ovary, Placenta, Uterus tissues are correlated with this protein. Breast Neoplasms, Congenital Abnormalities, Inflammation, Kidney Diseases, Lung Diseases, Lung Neoplasms, Necrosis, Ovarian Diseases are some of the diseases may be linked to HtrA3 Antibody (N-term) Blocking Peptide.