HJURP blocking peptide product blog
Tags: Blocking Peptide; HJURP; HJURP blocking peptide;
The HJURP hjurp (Catalog #MBS9219892) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The HJURP hjurp product has the following accession number(s) (GI #239938642) (NCBI Accession #Q8NCD3.2) (Uniprot Accession #Q8NCD3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Cellular Location: Nucleus, nucleolus. Chromosome, centromere. Note: Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage. Tissue Location: According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung. Brain Diseases, Breast Neoplasms, Cell Transformation, Neoplastic, Liver Diseases, Liver Neoplasms, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to HJURP Antibody (C-term) Blocking peptide. Blood, Brain, Liver, Lung, Lymph, Lymph Node, Muscle, Testis, Vascular tissues are correlated with this protein. HJURP also interacts with the following gene(s): CENPA, MIS18BP1, MSH5. The following patways have been known to be associated with this gene.