HDAC7 blocking peptide product blog
Tags: Blocking Peptide; HDAC7; HDAC7 blocking peptide;
The HDAC7 hdac7 (Catalog #MBS9218113) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The HDAC7 hdac7 product has the following accession number(s) (GI #169234807) (NCBI Accession #NP_056216) (Uniprot Accession #Q8WUI4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.
Cellular Location: Nucleus. Cytoplasm. Note: In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation. HDAC7 also interacts with the following gene(s): EP300, HDAC1, HDAC3, HDAC9, KAT2B, MEF2A, MEF2C, NCOR1, NCOR2. Brain Diseases, Cell Transformation, Neoplastic, Cognition Disorders, Disease Models, Animal, Fibrosis, Inflammation, Lung Diseases, Necrosis, Nervous System Diseases, Ovarian Diseases are some of the diseases may be linked to HDAC7 Antibody (C-term) Blocking Peptide. Blood, Bone, Brain, Heart, Liver, Lung, Muscle, Thymus, Thyroid, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.