HDAC4 blocking peptide product blog
Tags: HDAC4; Blocking Peptide; HDAC4 blocking peptide;
The HDAC4 hdac4 (Catalog #MBS9220132) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The HDAC4 hdac4 product has the following accession number(s) (GI #259016348) (NCBI Accession #P56524.3) (Uniprot Accession #P56524). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Cellular Location: Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Tissue Location: Ubiquitous. The following patways have been known to be associated with this gene. Adenocarcinoma, Atrophy, Carcinoma, Fibrosis, Heart Diseases, Inflammation, Intellectual Disability, Lung Neoplasms, Nervous System Diseases, Vascular Diseases are some of the diseases may be linked to HDAC4 Antibody (C-term) Blocking peptide. HDAC4 also interacts with the following gene(s): ANKRA2, HDAC3, MEF2C, MEF2D, NCOR2, SIRT1, SUMO1. Blood, Bone, Brain, Connective Tissue, Embryonic Tissue, Heart, Liver, Lung, Muscle, Prostate tissues are correlated with this protein.