|The HDAC11 hdac11 (Catalog #MBS9218154) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The HDAC11 hdac11 product has the following accession number(s) (GI #26394832) (NCBI Accession #Q96DB2.1) (Uniprot Accession #Q96DB2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Cellular Location: Nucleus. Note: Predominantly nuclear. Tissue Location: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis. The following patways have been known to be associated with this gene. Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Inflammation, Kidney Diseases, Necrosis, Neoplasms, Experimental, Neurobehavioral Manifestations, Ovarian Diseases are some of the diseases may be linked to HDAC11 Antibody (C-term) Blocking Peptide. Brain, Eye, Heart, Kidney, Liver, Lung, Nerve, Prostate, Testis, Thyroid tissues are correlated with this protein.