HDAC1 peptide product blog
Tags: HDAC1; Peptide; HDAC1 peptide; HDAC1, Human;
The HDAC1 hdac1 (Catalog #MBS396403) is a Peptide and is intended for research purposes only. The product is available for immediate purchase. The HDAC1, Human reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s HDAC1, Human can be used in a range of immunoassay formats including, but not limited to, Antibody Function Blocking. Researchers should empirically determine the suitability of the HDAC1 hdac1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The HDAC1 hdac1 product has the following accession number(s) (GI #13128860) (NCBI Accession #NP_004955.2) (Uniprot Accession #Q13547). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Acetylation of the tail of histone is known to cause chromatin to adopt a more ?open? 3D conformation, allowing trans factors grerater access to DNA. Histone acetyltransferases (HATs), complexes interact with sequence-specific activator proteins and target specific genes. In addition to histones, HATs acetylate non-histone proteins, implicating them in a wide variety of regulartory roles for these enzymes. By comparison, histone deacetylation promotes a more ?closed? chromatin conformation and in general leads to repression of gene activity. Mammalian histone deacetylases are divided into three classes on the basis of their similarity to various the yeast deacetylases. Class I (HDACs 1, 2, 3 and 8) related to the yeast Rpd3-like proteins, class II (HDACs 4, 5, 6, 7, 9 and 10) related to yeast Hda1-like proteins and class III related to the yeast protein Sir2. Inhibitors of HDAC have enormous potential as cancer therapeutic agents.
The following patways have been known to be associated with this gene. HDAC1 also interacts with the following gene(s): CHD4, DNMT1, KDM1A, MTA1, MTA2, RBBP4, RBBP7, RCOR1, SAP30, SIN3A. Breast Neoplasms, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Inflammation, Liver Diseases, Liver Neoplasms, Necrosis, Neoplasm Metastasis, Neoplasms, Nervous System Diseases are some of the diseases may be linked to HDAC1, Human. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Vascular tissues are correlated with this protein.