|The GTF2IRD1 gtf2ird1 (Catalog #MBS9223152) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The GTF2IRD1 gtf2ird1 product has the following accession number(s) (GI #21263630) (NCBI Accession #Q9UHL9.1) (Uniprot Accession #Q9UHL9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity).
Cellular Location: Nucleus. Tissue Location: Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested. Bone, Brain, Connective Tissue, Embryonic Tissue, Eye, Kidney, Liver, Muscle, Skin, Vascular tissues are correlated with this protein. Craniofacial Abnormalities, Heart Defects, Congenital, Heart Diseases, Hyperplasia, Kidney Diseases, Memory Disorders, Mental Disorders, Nervous System Diseases, Weight Loss, Williams Syndrome are some of the diseases may be linked to GTF2IRD1 Antibody (N-term) Blocking Peptide. GTF2IRD1 also interacts with the following gene(s): FOS, SMAD3, ZMYM5. The following patways have been known to be associated with this gene.