GSK3A blocking peptide product blog
Tags: GSK3A; Blocking Peptide; GSK3A blocking peptide;
The GSK3A gsk3a (Catalog #MBS9229721) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The GSK3A gsk3a product has the following accession number(s) (GI #12644292) (NCBI Accession #P49840.2) (Uniprot Accession #P49840). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
The following patways have been known to be associated with this gene. Blood, Bone, Brain, Connective Tissue, Embryonic Tissue, Heart, Liver, Lung, Muscle, Ovary tissues are correlated with this protein. Atherosclerosis, Brain Diseases, Cardiovascular Diseases, Disease Models, Animal, Fibrosis, Heart Diseases, Hyperplasia, Infertility, Male, Inflammation, Nervous System Diseases are some of the diseases may be linked to GSK3A Blocking Peptide (Center).