GSK1059615 kinase inhibitor product blog
Tags: Kinase Inhibitor; GSK1059615; GSK1059615 kinase inhibitor;
The GSK1059615 n/a (Catalog #MBS8506343) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given inhibitor. We\'ve tested the GSK1059615 with the following immunoassay(s):
Testing Data (GSK1059615 is a pan-PI3K reversible inhibitor with sub-nanomolar IC50 for PI3Kalpha (0.4 nM) and PI3Kbeta (0.6 nM) and shows low nanomolar activity towards gamma(5 nM),delta(2 nM) and mTOR(12 nM). GSK1059615 inhibits PI3K pathway in cells inducing G1 arrest, although apopto-sis was observed in a subset of cell lines. Breast tumor cells seem to be more sensitive to this compound. In xenograft mice, a complete tumor inhibition and regression were observed together with an increase in plasma insulin levels. [1])
GSK1059615 is a pan-PI3K reversible inhibitor with sub-nanomolar IC50 for PI3Kalpha (0.4 nM) and PI3Kbeta (0.6 nM) and shows low nanomolar activity towards gamma (5 nM), delta(2 nM) and mTOR(12 nM). GSK1059615 inhibits PI3K pathway in cells inducing G1 arrest, although apopto-sis was observed in a subset of cell lines. Breast tumor cells seem to be more sensitive to this compound. In xenograft mice, a complete tumor inhibition and regression were observed together with an increase in plasma insulin levels. [1].
Solubility: DMSO >=5 mg/mL - Water <1 mg/mL - Ethanol <1 mg/mL. Formula: C18H11N3O2S
CAS Number: 958852-01-2.