GRM2 assay system product blog
Tags: Grm2; Assay System; Metabotropic Glutamate Receptor 2; GRM2 assay system;
The GRM2 grm2 (Catalog #MBS433645) is an Assay System and is intended for research purposes only. The product is available for immediate purchase.cAMP dependent human GRM2 cell-based assay; cell-based high-throughput screening of human GRM2 inhibitors. Researchers should empirically determine the suitability of the GRM2 grm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GRM2 grm2 product has the following accession number(s) (GI #66529100) (NCBI Accession #NP_000830.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Background/Introduction: The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.