GPRC6A blocking peptide product blog
Tags: Blocking Peptide; GPRC6A; GPRC6A blocking peptide;
The GPRC6A gprc6a (Catalog #MBS9223780) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The GPRC6A gprc6a product has the following accession number(s) (GI #74745292) (NCBI Accession #Q5T6X5.1) (Uniprot Accession #Q5T6X5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.
Cellular Location: Cell membrane; Multi-pass membrane protein. Tissue Location: Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues. The following patways have been known to be associated with this gene. Adenocarcinoma, Body Weight Changes, Breast Neoplasms, Fatty Liver, Fibrosis, Inflammation, Musculoskeletal Abnormalities, Nervous System Malformations, Prostatic Diseases, Weight Gain are some of the diseases may be linked to GPRC6A Antibody (Center) Blocking Peptide. Connective Tissue, Kidney tissues are correlated with this protein.