|The GIT1 git1 (Catalog #MBS9226872) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The GIT1 git1 product has the following accession number(s) (GI #41393573) (NCBI Accession #NP_054749.2) (Uniprot Accession #Q9Y2X7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine- phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity).
Cellular Location: Cytoplasm. Note: Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin. GIT1 also interacts with the following gene(s): ARF6, ARHGEF6, ARHGEF7, CDC42, EPHA2, NCK1, PAK1, PLCG1, PTK2, PXN. Blood, Bone, Brain, Embryonic Tissue, Kidney, Liver, Lung, Muscle, Nerve, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Attention Deficit Disorder with Hyperactivity, Breast Neoplasms, Carcinoma, Carcinoma, Hepatocellular, Colonic Neoplasms, Inflammation, Liver Diseases, Neoplasm Invasiveness, Neoplasm Metastasis, Vascular Diseases are some of the diseases may be linked to GIT1 (Y554) Antibody (C-term) Blocking peptide.