GDF8 recombinant protein product blog
Tags: Myostatin; Recombinant Protein; GDF8 recombinant protein; GDF8;
The GDF8 mstn (Catalog #MBS553028) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase.The GDF8 mstn product has the following accession number(s) (GI #4885259) (NCBI Accession #NP_005250.1) (Uniprot Accession #O14793). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including Myostatin are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Biological Activity: The ED(50) was determined by the dose-dependentproliferation inhibition of human MPC-11 cells was found to be in the range of.0-40.0 ng/ml.
Host Note: Optimized DNA sequence encoding Human Myostatin mature chain was expressed in Escherichia Coli. Endotoxin: Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers
Molecular Weight Note: Native human Myostatin, generated by the proteolytic removal of the signal peptide
and propeptide, molecule has a calculated molecular mass of approximately 13 kDa.
Recombinant human Myostatin is a disulfide-linked homodimeric protein consisting of two 110 amino acid residue subunits, and migrates as an approximately 25 kDa protein under non-reducing conditions and as a 13kDa protein under reducing conditions in SDS-PAGE. Brain, Connective Tissue, Embryonic Tissue, Eye, Heart, Lung, Muscle, Placenta tissues are correlated with this protein. GDF8 also interacts with the following gene(s): ACVR2B, FSTL3, SGTA, TCAP. The following patways have been known to be associated with this gene. Critical Illness, Hypertrophy, Hypogonadism are some of the diseases may be linked to Human Myostatin Recombinant.