|The GDF8 gdf8 (Catalog #MBS542795) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s GDF8 / Myostatin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western Blot: 1:500. Researchers should empirically determine the suitability of the GDF8 gdf8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The GDF8 gdf8 product has the following accession number(s) (GI #113912637) (NCBI Accession #ABI48514) (Uniprot Accession #Q53S46). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Acts specifically as a negative regulator of skeletal muscle growth.
Immunogen: Purified Protein. Molecular Function: Cytokine activity; Growth factor activity; heparin binding; identical protein binding; receptor binding; transforming growth factor beta receptor binding
Structure: Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3. Belongs to the TGF-beta family.
Subcellular Location: Secreted; Cytoplasm. Brain, Connective Tissue, Embryonic Tissue, Eye, Heart, Lung, Muscle, Placenta tissues are correlated with this protein. GDF8 also interacts with the following gene(s): ACVR1B, ACVR2B, AKT1, DCN, FSTL3, MYL1, MYOD1, TGFBR1, WFIKKN2, WNT4. The following patways have been known to be associated with this gene. Atrophy, Disease Models, Animal, Fibrosis, Hyperplasia, Hypertrophy, Inflammation, Insulin Resistance, Necrosis, Nervous System Diseases, Weight Loss are some of the diseases may be linked to GDF8 / Myostatin Positive Control.