GDC-0449 kinase inhibitor product blog
Tags: Kinase Inhibitor; GDC-0449; GDC-0449 kinase inhibitor;
The GDC-0449 n/a (Catalog #MBS8506298) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given inhibitor. We\'ve tested the GDC-0449 with the following immunoassay(s):
Testing Data
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. It targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO. It inhibits the growth of primary pancreatic xenografts without non-specifically inhibiting pancreatic cell proliferation in vitro and has recently entered the clinic. It also inhibits ABCG2, Pgp, and MRP1-important ABC transporters associated with MDR. The IC50 values of GDC-0449 (Vismodegib) for inhibition of ABCG2 and Pgp were about1.4 and 3.0 muM, respectively. It has been used to treat medulloblastoma in animal models. [1][2][3][4].
Solubility: DMSO >=84mg/mL - Water <1mg/mL - Ethanol >=10mg/mL. Formula: C19H14Cl2N2O3S
CAS Number: 879085-55-9.