GCGR blocking peptide product blog
Tags: Blocking Peptide; GCGR; GCGR blocking peptide;
The GCGR gcgr (Catalog #MBS9227918) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The GCGR gcgr product has the following accession number(s) (GI #1346144) (NCBI Accession #P47871.1) (Uniprot Accession #P47871). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Cellular Location: Cell membrane; Multi-pass membrane protein. Note: Is rapidly internalized after ligand-binding. Kidney, Liver, Pancreas tissues are correlated with this protein. Cardiovascular Diseases, Diabetes Mellitus, Type 2, Fatty Liver, Hyperplasia, Hypertension, Hypertrophy, Inflammation, Liver Diseases, Necrosis, Weight Loss are some of the diseases may be linked to GCGR Antibody (Center) Blocking Peptide. The following patways have been known to be associated with this gene.