|The Galanthus nivalis n/a (Catalog #MBS656289) is a Lectin produced from Galanthus nivalis (snowdrop bulb) and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Galanthus nivalis can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the Galanthus nivalis n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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Galanthus nivalis agglutinin (GNA) is a small molecular weight tetramer consisting of subunits of about 13,000D. This lectin contains little or no carbohydrate. Unlike most mannose-specific lectins, it is not a metalloprotein and does not require Ca++ or Mn++ for binding. Binding seems to be preferentially directed toward structures containing (a-1,3) mannose residues. In contrast to most mannose-binding lectins, GNA will not bind alpha linked glucose. Reports indicate that this lectin binds IgM, but not bind IgG immunoglobulin classes of rat and mouse. The only protein from human serum reported to bind to this lectin is a2-macroglobulin.
Activity: 15ug/ml will agglutinate human type O erythrocytes.
Carbohydrate Specificity: Mannose. Inhibiting/Eluting Sugar: 100mM-200mM a-methyl mannoside
Inhibitory Carbohydrate: Mannose a-1,3-mannose
Mannose (> 0.2M).