|The GAL80 gal80 (Catalog #MBS633737) is a Peptide and is intended for research purposes only. The product is available for immediate purchase.
The GAL80 gal80 product has the following accession number(s) (GI #6323590) (NCBI Accession #NP_013661.1) (Uniprot Accession #P04387). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The Gal80p complex consists of three components encoded by GAL4,GAL80, and Gal3. These components form a herterotrimeric complex. S. cerevisiae responds to galactose as sole carbon source by activating the GAL genes. The switch from expressed to activated gene expression involves the interplay of three proteins: the activator Gal4p, the repressor Gal80p, the inducer Gal3p, and two small molecules ATP and galactose. In the absence of galactose the transcriptional activity of Gal4p is inhibited by Gal80p. The association of galactose and ATP with Gal3p promote its interaction with the Gal4p -Gal80p complex. This interaction allows Gal4p to be freed from Gal80p inhibition and activate transcription. It has also been shown that Gal1p can also relieve the Gal80 repression of Gal4p in the presence of galactose, although less efficiently than Gal3p.
Sequence (linear): DERGNRLGQRVPKTVC. Quality Control: HPLC, MS. GAL80 also interacts with the following gene(s): GAL1, GAL2, GAL3, GAL4, GAL7, MDM30, SNF1.