|The GABRB2 gabrb2 (Catalog #MBS9220871) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The GABRB2 gabrb2 product has the following accession number(s) (GI #292495010) (NCBI Accession #P47870.2) (Uniprot Accession #P47870). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.
Cellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Tissue Location: Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. GABRB2 also interacts with the following gene(s): GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRG2, GABRG3. The following patways have been known to be associated with this gene. Ataxia, Brain Diseases, Central Nervous System Diseases, Disease Models, Animal, Epilepsy, Nervous System Diseases, Schizophrenia, Seizures, Substance Withdrawal Syndrome, Substance-Related Disorders are some of the diseases may be linked to GABRB2 Antibody (C-term) Blocking Peptide. Blood, Brain, Eye, Intestine, Kidney, Muscle, Thyroid tissues are correlated with this protein.