FOXA1 blocking peptide product blog
Tags: Blocking Peptide; FOXA1; FOXA1 blocking peptide;
The FOXA1 foxa1 (Catalog #MBS9221104) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The FOXA1 foxa1 product has the following accession number(s) (GI #296434509) (NCBI Accession #P55317.2) (Uniprot Accession #P55317). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a \'pioneer\' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5\'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3\' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at \'Lys-5\' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis- acting regulatory regions of these genes. Involved in glucose homeostasis.
Cellular Location: Nucleus. Tissue Location: Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas. FOXA1 also interacts with the following gene(s): ESR1, FOXA2, INS, NKX2-1, NKX3-1, SCGB1A1, SHH, TFF1, TTR. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Disease Models, Animal, Liver Diseases, Liver Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasm Metastasis, Prostatic Neoplasms are some of the diseases may be linked to FOXA1 Antibody (Center S286) Blocking Peptide. Bladder, Brain, Embryonic Tissue, Intestine, Kidney, Liver, Lung, Mammary Gland, Nerve, Prostate tissues are correlated with this protein.