|The FLT1 flt1 (Catalog #MBS142780) is a Recombinant Protein produced from Insect Cells and is intended for research purposes only. The product is available for immediate purchase.
The FLT1 flt1 product has the following accession number(s) (GI #229892220) (NCBI Accession #NP_001153392.1) (Uniprot Accession #P17948). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Signal Peptide:MV SYWDTGVLLC ALLSCLLLTG SSSG.Solub le sFlt.1(D3) : SKLKDPELSL KGTQHIMQAG QTLHLQCRGE AAHKWSLPEM VSKESERLSI TKSACGRNGK QFCSTLTLNT AQANHTGFYS CKYLAVPTSK KKETESAIYI FISDTGRPFV EMYSEIPEII HMTEGRELVI PCRVTSPNIT VTLKKFPLDT LIPDGKRIIW DSRKGFIISN ATYKEIGLLT CEATVNGHLY KTNYLTHRQT NTIIDVQIST PRPVKLLRGH TLVLNCTATT PLNTRVQMTW SYPDEKNKRA SVRRRIDQSN SHANIFYSVL TIDKMQNKDK GLYTCRVRSG PSFKSVNTSV HIYDKAFITV KH.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including Vascular Endothelial Growth Factor receptor-1 D1-3 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Solubility: It is recommended to reconstitute the lyophilized FLT1 D3 in sterile water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity: The activity of FLT1D1-3 was determined by its ability to abolish the binding of iodinated VEGF to solid surfaces or cell surfaces receptors, and in Far-Western and cross-linking experiments with iodinated VEGF. Adenocarcinoma, Brain Diseases, Disease Models, Animal, Heart Diseases, Hypertension, Inflammation, Kidney Diseases, Nervous System Diseases, Pre-Eclampsia, Proteinuria are some of the diseases may be linked to Recombinant Human Vascular Endothelial Growth Factor receptor-1 D1-3. The following patways have been known to be associated with this gene. Blood, Bone, Embryonic Tissue, Heart, Kidney, Liver, Lung, Muscle, Placenta, Vascular tissues are correlated with this protein. FLT1 also interacts with the following gene(s): EPAS1, FIGF, HIF1A, NRP1, PGF, VEGFA, VEGFB, VEGFC.