|The FKBP6 fkbp6 (Catalog #MBS9222134) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The FKBP6 fkbp6 product has the following accession number(s) (GI #13124184) (NCBI Accession #O75344.1) (Uniprot Accession #O75344). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
Cellular Location: Cytoplasm, cytosol. Nucleus. Chromosome. Note: Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity). Tissue Location: Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney. Brain, Lung, Ovary, Testis tissues are correlated with this protein. Congenital Abnormalities, Heart Defects, Congenital, Infertility, Female, Infertility, Male, Neoplasms, Experimental, Oligospermia, Uterine Cervical Neoplasms are some of the diseases may be linked to FKBP6 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene.