FGR blocking peptide product blog
Tags: Blocking Peptide; FGR; FGR blocking peptide;
The FGR fgr (Catalog #MBS9227184) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The FGR fgr product has the following accession number(s) (GI #125358) (NCBI Accession #P09769.2) (Uniprot Accession #P09769). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK- dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Cellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton Mitochondrion inner membrane. Mitochondrion intermembrane space. Note: Detected in mitochondrial intermembrane space and at inner membranes (By similarity) Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. Tissue Location: Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes. FGR also interacts with the following gene(s): CBL, CSK, HRAS, PXN, STAT3, SYK. Cardiovascular Diseases, Cell Transformation, Neoplastic, Heart Diseases, Hypertension, Inflammation, Kidney Diseases, Lung Diseases, Necrosis, Premature Birth, Weight Gain are some of the diseases may be linked to FGR Antibody (N-term) Blocking Peptide. Blood, Bone, Brain, Embryonic Tissue, Heart, Liver, Lung, Placenta, Uterus, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.