FGFR2 blocking peptide product blog
Tags: FGFR2; Blocking Peptide; FGFR2 blocking peptide;
The FGFR2 fgfr2 (Catalog #MBS9227100) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The FGFR2 fgfr2 product has the following accession number(s) (GI #120049) (NCBI Accession #P21802.1) (Uniprot Accession #P21802). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note: Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded Isoform 3: Cell membrane; Single-pass type I membrane protein. Note: After ligand binding, the activated receptor is rapidly internalized and degraded Isoform 19: Secreted. Bone, Brain, Embryonic Tissue, Eye, Lung, Muscle, Prostate, Skin, Stomach, Vascular tissues are correlated with this protein. Abnormalities, Multiple, Acrocephalosyndactylia, Breast Neoplasms, Craniofacial Abnormalities, Craniofacial Dysostosis, Craniosynostoses, Limb Deformities, Congenital, Pfeiffer type acrocephalosyndactyly, Skin Diseases, Stomach Neoplasms are some of the diseases may be linked to FGFR2 Antibody (N-term R22) Blocking Peptide. The following patways have been known to be associated with this gene. FGFR2 also interacts with the following gene(s): FGF1, FGF10, FGF2, FGF3, FGF4, FGF6, FGF7, FGF8, FGF9, GRB2.