FAN1 blocking peptide product blog
Tags: Blocking Peptide; FAN1; MTMR15; FAN1 blocking peptide;
The FAN1 fan1 (Catalog #MBS9225583) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The FAN1 fan1 product has the following accession number(s) (GI #160410012) (NCBI Accession #Q9Y2M0.4) (Uniprot Accession #Q9Y2M0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5\'-3\' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3\'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5\'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3\' flap (PubMed:25430771). Also has endonuclease activity toward 5\'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).
Cellular Location: Nucleus Note: Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016) Localizes to stalled replication forks via its UBZ-type zinc finger (PubMed:20935496). Bone Marrow, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung tissues are correlated with this protein. FAN1 also interacts with the following gene(s): FANCD2, FANCI, MTMR10, PMS2, TRPM1. Breast Neoplasms, Chromosome Breakage, Fibrosis, Kidney Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental, Pancreatic Neoplasms, Proteinuria are some of the diseases may be linked to MTMR15 Antibody (N-term) Blocking peptide. The following patways have been known to be associated with this gene.