ESR2 blocking peptide product blog
Tags: Blocking Peptide; Esr2; ESR2 blocking peptide;
The ESR2 esr2 (Catalog #MBS9224412) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The ESR2 esr2 product has the following accession number(s) (GI #6166154) (NCBI Accession #Q92731.2) (Uniprot Accession #Q92731). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Cellular Location: Nucleus. Tissue Location: Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain. Brain, Lung, Testis tissues are correlated with this protein. ESR2 also interacts with the following gene(s): ESR1, FOS, NCOA1, NCOA2, NCOA3, NCOR2, NOS3, NR0B1, SRC. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Colorectal Neoplasms, Endometriosis, Infertility, Female, Infertility, Male, Inflammation, Prostatic Neoplasms are some of the diseases may be linked to ESR2 Antibody(Center) Blocking peptide. The following patways have been known to be associated with this gene.