|The ERO1L ero1a (Catalog #MBS9219820) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The ERO1L ero1a product has the following accession number(s) (GI #50400608) (NCBI Accession #Q96HE7.2) (Uniprot Accession #Q96HE7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
Cellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side Note: The association with ERP44 is essential for its retention in the endoplasmic reticulum. Tissue Location: Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. Cardiovascular Diseases, Heart Diseases are some of the diseases may be linked to ERO1L Antibody (C-term) Blocking peptide. Heart, Lymph Node tissues are correlated with this protein. The following patways have been known to be associated with this gene.