|The Ern1 ern1 (Catalog #MBS9220607) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The Ern1 ern1 product has the following accession number(s) (GI #51316086) (NCBI Accession #Q9EQY0.1) (Uniprot Accession #Q9EQY0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Cellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Tissue Location: Ubiquitously expressed. High levels in thymus, liver and lung. In the brain, preferentially expressed in cortical, hippocampal and olfactory neurons. The following patways have been known to be associated with this gene. Blood, Bone Marrow, Brain, Embryonic Tissue, Eye, Intestine, Kidney, Liver, Lung, Pancreas tissues are correlated with this protein. Brain Diseases, Disease Models, Animal, Drug-Induced Liver Injury, Fatty Liver, Hyperglycemia, Inflammation, Insulin Resistance, Liver Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to Mouse Ern1 Antibody (C-term) Blocking Peptide. Ern1 also interacts with the following gene(s): Atf6, Bak1, Hspa5, Syvn1, Traf2, Xbp1.