ERBB2 blocking peptide product blog
Tags: ERBB2; Blocking Peptide; ERBB2 blocking peptide; ERBB2 (Y1139);
The ERBB2 erbb2 (Catalog #MBS9225285) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The ERBB2 erbb2 product has the following accession number(s) (GI #119533) (NCBI Accession #P04626.1) (Uniprot Accession #P04626). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus Note: Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1 Isoform 3: Cytoplasm. Nucleus. Tissue Location: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Liver, Lung, Lymph Node, Mammary Gland, Prostate, Stomach tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinogenesis, Disease Progression, Gastrointestinal Neoplasms, Lung Neoplasms, Lymphatic Metastasis, Neoplasm Metastasis, Neoplasms, Experimental, Recurrence are some of the diseases may be linked to Phospho-ERBB2(Y1139) Antibody Blocking peptide.