|The EPHB4 ephb4 (Catalog #MBS543650) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Ephrin Receptor B4 can be used in a range of immunoassay formats including, but not limited to, Immunocompetition, Immunodepletion.
Western Blot: 1:500. Researchers should empirically determine the suitability of the EPHB4 ephb4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The EPHB4 ephb4 product has the following accession number(s) (GI #32528301) (NCBI Accession #NP_004435) (Uniprot Accession #P54760). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Antigenic Blocking Peptide Ephrin type-B receptor 4 precursor Antibody
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
Immunogen: Synthetic Peptide
Expression: Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung,. Molecular Function: ATP-binding, Nucleotide-binding
Structure: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
Subcellular Location: Cell Membrane. The following patways have been known to be associated with this gene. EPHB4 also interacts with the following gene(s): EFNA1, EFNA2, EFNA5, EFNB1, EFNB2, EFNB3, PIK3CA, PTEN, RAC1, VEGFA. Brain Diseases, Breast Neoplasms, Carcinoma, Hepatocellular, Cardiovascular Diseases, Fibrosis, Inflammation, Lung Diseases, Lung Neoplasms, Neoplasms, Experimental, Vascular Diseases are some of the diseases may be linked to Eprhin Receptor B4 Antibody Antigenic Blocking Peptide. Bone, Brain, Embryonic Tissue, Eye, Heart, Liver, Lung, Muscle, Prostate, Vascular tissues are correlated with this protein.