EPHA4 blocking peptide product blog
Tags: Blocking Peptide; EPHA4; EPHA4 blocking peptide;
The EPHA4 epha4 (Catalog #MBS9229540) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The EPHA4 epha4 product has the following accession number(s) (GI #1711371) (NCBI Accession #P54764.1) (Uniprot Accession #P54764). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-An and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at \'Tyr-15\' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Early endosome Note: Clustered upon activation and targeted to early endosome. Tissue Location: Ubiquitous. EPHA4 also interacts with the following gene(s): EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, NGEF. The following patways have been known to be associated with this gene. Adenocarcinoma, Atherosclerosis, Breast Neoplasms, Cardiovascular Diseases, Congenital Abnormalities, Disease Models, Animal, Embryo Loss, Inflammation, Necrosis, Prostatic Neoplasms are some of the diseases may be linked to EPHA4 Blocking Peptide (Center). Blood, Bone, Brain, Embryonic Tissue, Eye, Heart, Kidney, Muscle, Skin, Vascular tissues are correlated with this protein.