EGFR blocking peptide product blog
Tags: EGFR; Blocking Peptide; EGFR blocking peptide; EGFR (Y998);
The EGFR egfr (Catalog #MBS9225117) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The EGFR egfr product has the following accession number(s) (GI #2811086) (NCBI Accession #P00533.2) (Uniprot Accession #P00533). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. Note: In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF). Tissue Location: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. Adenocarcinoma, Breast Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Colorectal Neoplasms, Disease Progression, Head and Neck Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma are some of the diseases may be linked to Phospho-EGFR(Y998) Antibody Blocking peptide. EGFR also interacts with the following gene(s): CBL, CBLB, EPS15, GRB2, HSP90AA1, PLCG1, PTPN1, SHC1, SRC, STAT3. Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.