|The EBI3 ebi3 (Catalog #MBS9228834) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The EBI3 ebi3 product has the following accession number(s) (GI #14577917) (NCBI Accession #NP_005746.2) (Uniprot Accession #Q14213). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Cellular Location: Secreted. EBI3 also interacts with the following gene(s): IL27, IL27RA, IL6ST, JAK2, STAT1, STAT3, STAT4. The following patways have been known to be associated with this gene. Cardiovascular Diseases, Disease Models, Animal, Drug-Related Side Effects and Adverse Reactions, Heart Diseases, Inflammation, Kidney Diseases, Liver Diseases, Lung Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to EBI3 Blocking Peptide (C-term). Brain, Embryonic Tissue, Eye, Lymph Node, Pancreas, Placenta, Tonsil, Uterus tissues are correlated with this protein.