|The DSTYK dstyk (Catalog #MBS9230214) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The DSTYK dstyk product has the following accession number(s) (GI #296434486) (NCBI Accession #Q6XUX3.2) (Uniprot Accession #Q6XUX3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.
Cellular Location: Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction. Note: Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. Tissue Location: Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Learning Disorders, Memory Disorders, Urogenital Abnormalities are some of the diseases may be linked to DSTYK Blocking Peptide (N-Term). Blood, Brain tissues are correlated with this protein.