DPP4 blocking peptide product blog
Tags: DPP4; Blocking Peptide; DPP4 blocking peptide;
The DPP4 dpp4 (Catalog #MBS9228662) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The DPP4 dpp4 product has the following accession number(s) (GI #18765694) (NCBI Accession #NP_001926) (Uniprot Accession #P27487). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
Cellular Location: Dipeptidyl peptidase 4 soluble form: Secreted. Note: Detected in the serum and the seminal fluid. Tissue Location: Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. The following patways have been known to be associated with this gene. Cardiovascular Diseases, Fibrosis, Heart Diseases, Hyperglycemia, Hypertension, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Weight Loss are some of the diseases may be linked to DPP4 Blocking Peptide (N-term). Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Pancreas, Vascular tissues are correlated with this protein.