|The DDX42 ddx42 (Catalog #MBS9230470) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The DDX42 ddx42 product has the following accession number(s) (GI #74750541) (NCBI Accession #Q86XP3.1) (Uniprot Accession #Q86XP3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.
Cellular Location: Cytoplasm. Nucleus speckle. Nucleus, Cajal body. Note: Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles. Tissue Location: Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets. The following patways have been known to be associated with this gene. Anemia, Carcinoma, Inflammation are some of the diseases may be linked to DDX42 Blocking Peptide (N-Term). Blood, Bone, Brain, Liver, Lung, Muscle, Pancreas, Thymus, Tonsil tissues are correlated with this protein.