Ddr2 blocking peptide product blog
Tags: Blocking Peptide; DDR2; Ddr2 blocking peptide;
The Ddr2 ddr2 (Catalog #MBS9220947) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Ddr2 ddr2 product has the following accession number(s) (GI #2497565) (NCBI Accession #Q62371.2) (Uniprot Accession #Q62371). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: Widely expressed. Detected in lung, ovary, skin and in testis Leydig cells (at protein level). Widely expressed. Detected at high levels in heart, lung, skeletal muscle, central nervous system (CNS) and kidney, and at lower levels in brain and testis. Detected in chondrocytes in tibia growth plates of young mice. Bone, Bone Marrow, Brain, Embryonic Tissue, Liver, Lung, Lymph Node, Prostate, Skin, Testis tissues are correlated with this protein. Atherosclerosis, Cardiovascular Diseases, Fibrosis, Heart Diseases, Hyperplasia, Inflammation, Kidney Diseases, Liver Diseases, Lung Diseases, Necrosis are some of the diseases may be linked to Mouse Ddr2 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene. Ddr2 also interacts with the following gene(s): Atf4, Col11a1, Col1a2, Mmp13, Mmp2, Ptpn11.