Ddr1 blocking peptide product blog
Tags: Blocking Peptide; DDR1; DDR1 blocking peptide;
The Ddr1 ddr1 (Catalog #MBS9229307) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Ddr1 ddr1 product has the following accession number(s) (GI #2506799) (NCBI Accession #Q03146.2) (Uniprot Accession #Q03146). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: Detected in the cochlea and the organ of Corti in the inner ear. Isoform 1 is predominant and is expressed in developing embryo and adult brain. Isoform 2 is expressed in various epithelial cells. Adenocarcinoma, Breast Neoplasms, Fibrosis, Inflammation, Kidney Diseases, Lung Neoplasms, Necrosis, Neoplasm Metastasis, Neoplasms, Experimental, Vascular Diseases are some of the diseases may be linked to Mouse Ddr1 Blocking Peptide (Center). The following patways have been known to be associated with this gene. Bone, Brain, Connective Tissue, Embryonic Tissue, Heart, Kidney, Lung, Mammary Gland, Muscle, Skin tissues are correlated with this protein. Ddr1 also interacts with the following gene(s): Cdh1, Mmp2, Myh9, Nov, Ptgs2, Ptpn11, Shc1.