|The CYR61 cyr61 (Catalog #MBS9230402) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CYR61 cyr61 product has the following accession number(s) (GI #3023601) (NCBI Accession #O00622.1) (Uniprot Accession #O00622). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Cellular Location: Secreted. Brain Diseases, Breast Neoplasms, Disease Models, Animal, Fibrosis, Inflammation, Lung Neoplasms, Necrosis, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to CYR61 Blocking Peptide (Center). CYR61 also interacts with the following gene(s): CTNNB1, FOS, ITGAV, JUN, MKL1, RHOA, SRF. The following patways have been known to be associated with this gene. Bone, Brain, Connective Tissue, Embryonic Tissue, Liver, Lung, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein.