|The CYP1B1 cyp1b1 (Catalog #MBS9227357) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CYP1B1 cyp1b1 product has the following accession number(s) (GI #48429256) (NCBI Accession #Q16678.2) (Uniprot Accession #Q16678). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
Cellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein Mitochondrion. Tissue Location: Expressed in many tissues. CYP1B1 also interacts with the following gene(s): AHR, COMT, EPHX1, GSTA1, GSTM1, GSTP1, GSTT1, HSD17B6, UGT1A1, UGT1A6. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Squamous Cell, Cardiovascular Diseases, Glaucoma 3, Primary Congenital, A, Inflammation, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental, Prostatic Neoplasms are some of the diseases may be linked to CYP1B1 Antibody (Center) Blocking Peptide. Blood, Brain, Eye, Heart, Kidney, Liver, Lung, Prostate, Skin, Vascular tissues are correlated with this protein.