CTCFL blocking peptide product blog
Tags: Blocking Peptide; CTCFL; CTCFL blocking peptide;
The CTCFL ctcfl (Catalog #MBS9230509) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The CTCFL ctcfl product has the following accession number(s) (GI #313104098) (NCBI Accession #Q8NI51.2) (Uniprot Accession #Q8NI51). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 \'Arg-3\' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Cellular Location: Cytoplasm. Nucleus. Tissue Location: Testis specific. Specifically expressed in primary spermatocytes. Bone, Bone Marrow, Eye, Kidney, Testis tissues are correlated with this protein. Breast Neoplasms, Carcinoma, Disease Models, Animal, Hyperplasia, Immune System Diseases, Infertility, Male, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Experimental, Ovarian Neoplasms are some of the diseases may be linked to CTCFL Blocking Peptide (C-Term).