Csk blocking peptide product blog
Tags: CSK; Blocking Peptide; CSK blocking peptide;
The Csk csk (Catalog #MBS9221645) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Csk csk product has the following accession number(s) (GI #341940406) (NCBI Accession #P41241.2) (Uniprot Accession #P41241). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
Cellular Location: Cytoplasm. Cell membrane. Note: Mainly cytoplasmic, also present in lipid rafts. Tissue Location: Ubiquitous, but most abundant in thymus and spleen, as well as in neonatal brain. Csk also interacts with the following gene(s): Cd247, Itgb3, Lck, Pag1, Ptpn11, Ptpn6, Ptprc, Pxn, Src. The following patways have been known to be associated with this gene. Blood, Bone, Bone Marrow, Brain, Heart, Kidney, Liver, Lung, Muscle, Skin tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Heart Diseases, Hypertension, Inflammation, Kidney Diseases, Necrosis, Neoplasm Invasiveness are some of the diseases may be linked to Mouse Csk Antibody (C-term) Blocking Peptide.