CREB1 peptide product blog
Tags: Peptide; CREB; CREB1; CREB1 peptide;
The CREB1 creb1 (Catalog #MBS659747) is a Peptide and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s CREB can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA, Western Blot or for antigen applications in immunological protocols. Researchers should empirically determine the suitability of the CREB1 creb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CREB1 creb1 product has the following accession number(s) (GI #33694240) (NCBI Accession #AAQ24858.1) (Uniprot Accession #P16220). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given peptide. We\'ve tested the CREB, phosphorylated (Ser133) (cAMP Response Element Binding Protein) Blocking Peptide with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts from forskolin and IBMX treated SK-N-MC cells, using C7915-10Awith and without preincubation with phospho-peptide.)
Immunohistochemistry (IHC) (Immunohistochemical staining of paraffin-embedded human breast carcinoma using Phospho-CREB (Ser133) Antibody preincubated with irrelevant control peptide (left) and C7915-10A(right).)
Transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth or neurotrophic factors. Protein kinase An and the calmodulin-dependent protein kinase CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity (1,2). Phosphorylation at Ser133 is also mediated by p44/42 MAP kinase, p90RSK, p38 MAP kinase and MSK1 (3-5). CREB appears to play an important role in learning and memory in both flies and mice.
Produced by immunizing rabbits with a synthetic phosphopeptide (KLH coupled) corresponding to residues around Ser133 of human CREB.
The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. CREB1 also interacts with the following gene(s): AKT1, CREBBP, EP300, FOS, JUN, MAPK1. Cognition Disorders, Depressive Disorder, Fibrosis, Inflammation, Learning Disorders, Liver Diseases, Memory Disorders, Necrosis, Neoplasms, Nervous System Diseases are some of the diseases may be linked to CREB, phosphorylated (Ser133) (cAMP Response Element Binding Protein) Blocking Peptide.