|The CNOT7 cnot7 (Catalog #MBS9218145) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CNOT7 cnot7 product has the following accession number(s) (GI #41713629) (NCBI Accession #Q9UIV1.3) (Uniprot Accession #Q9UIV1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Has 3\'-5\' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity.
Cellular Location: Nucleus. Cytoplasm, P-body. Note: NANOS2 promotes its localization to P-body. CNOT7 also interacts with the following gene(s): BTG2, CNOT1, CNOT2, CNOT6, CNOT6L, RQCD1, TOB1. The following patways have been known to be associated with this gene. Blood, Brain, Embryonic Tissue, Liver tissues are correlated with this protein. Breast Neoplasms, Infertility, Female, Lung Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to CAF-1 Antibody (N-term) Blocking peptide.