|The CIR1 cir1 (Catalog #MBS9220538) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CIR1 cir1 product has the following accession number(s) (GI #74727790) (NCBI Accession #Q86X95.1) (Uniprot Accession #Q86X95). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Cellular Location: Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note: Colocalizes with NEK6 in the centrosome. Tissue Location: Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas. Blood, Embryonic Tissue, Intestine, Kidney, Lung, Muscle, Skin, Uncharacterized Tissue tissues are correlated with this protein. The following patways have been known to be associated with this gene.