Chemokine assay system product blog
Tags: Chemokine; Assay System; Chemokine assay system;
The Chemokine n/a (Catalog #MBS433629) is an Assay System and is intended for research purposes only. The product is available for immediate purchase.cAMP dependent human CCR5 cell-based assay; cell-based high-throughput screening of human CCR5 inhibitors. Researchers should empirically determine the suitability of the Chemokine n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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Background/Introduction: CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.