|The CHD5 chd5 (Catalog #MBS9230603) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The CHD5 chd5 product has the following accession number(s) (GI #51701343) (NCBI Accession #Q8TDI0.1) (Uniprot Accession #Q8TDI0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated \'Lys-27\' (H3K27me3) and non- methylated \'Lys-4\' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at \'Lys- 27\' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.
Cellular Location: Nucleus. Note: Associates with heterochromatin. Tissue Location: Preferentially expressed in total brain, fetal brain, and cerebellum. It is also moderately expressed in the adrenal gland and detected in testis. Brain, Eye, Intestine, Muscle, Testis, Uncharacterized Tissue tissues are correlated with this protein. Breast Neoplasms, Cell Transformation, Neoplastic, Colorectal Neoplasms, Genital Diseases, Female, Gonadal Disorders, Heart Diseases, Neoplasm Invasiveness, Neuroblastoma, Recurrence, Respiratory Tract Diseases are some of the diseases may be linked to CHD5 Blocking Peptide (N-Term).