CENPE blocking peptide product blog
Tags: Blocking Peptide; CENPE; CENPE blocking peptide;
The CENPE cenpe (Catalog #MBS9223017) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The CENPE cenpe product has the following accession number(s) (GI #160358869) (NCBI Accession #Q02224.2) (Uniprot Accession #Q02224). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle.
Cellular Location: Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note: Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division. Anemia, Atrophy, Breast Neoplasms, Cardiovascular Diseases, Fetal Growth Retardation, Fibrosis, Lung Diseases, Lung Neoplasms, Neoplasms, Experimental, Skin Neoplasms are some of the diseases may be linked to CENPE Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene. Brain, Connective Tissue, Embryonic Tissue, Kidney, Liver, Lung, Skin tissues are correlated with this protein.